Fen Z. Hu, Ph.D.

We are part of the West Penn Allegheny Health System

Fen Z. Hu, Ph.D.

Operations Director, Center for Genomic Sciences
Allegheny-Singer Research Institute
320 East North Avenue
Pittsburgh, PA 15212
Phone: (412) 359-8094
Fax: (412) 359-4377
Email: fhu@wpahs.org

Education

Ph.D. Molecular and Cell Biology and Genetics. Dissertation: The Genetics of Human Severe Pediatric Gastroesophageal Reflux Disease. Drexel University College of Medicine, Philadelphia, PA. 2004.

M.S. Molecular and Human Genetics. Thesis : Mapping Of A Gene For Severe Pediatric Gastroesophageal Reflux To Chromosome 13q14. Masters Thesis, MCP-Hahnemann School of Medicine, Philadelphia, PA. 1999.

Academic and Professional Appointments

2007-present	Assistant Professor of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA.

2003-present	Operations Director, Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, PA.

1998-2002	Laboratory Manager, Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, PA.

1997-1998	Senior Research Assistant, Center for Genomic Sciences, Allegheny University of Health Sciences, Pittsburgh, PA.

1997	Research Specialist 3, Center for Genomic Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Professional Interests

Bacterial biofilm pathogenesis, current projects include:

Testing the distributed genome hypothesis
Identifying and characterizing chronic virulence genes in Haemophilus influenzae, Streptococcus pneumoniae, and Pseudomonas aeruginosa
Assessing the degree of genomic plasticity among isolates of pathogenic bacterial species

The genetics of inherited human diseases, current projects include:

Pediatric gastroesophageal reflux disease
Craniosynostoses
Dupuytren's contracture
Ear development

Development of efficient laboratory and computational systems

Design of an integrated high throughput automated molecular biological laboratory http://www.centerforgenomicsciences.org/facilities/robotic.html
Algorithm development for bioinformatic processes including: genotyping, allele calling, binning, re-arraying, and array analysis.

Significant Scientific and Computational Accomplishments

Mapping of a gene for severe pediatric gastroesophageal reflux disease
Mapping of a gene for Dupuytren contracture
Cloning of genes associated with scarless wound healing
Design and Development of a Suite of Software Programs for automated handling of genotypic data
Design and Development of a Suite of Software Programs for interfacing and integrating multiple
robotic platforms used for gene array development and analyses

Memberships in Scientific Societies

Association for Research in Otolaryngology
American Society for Human Genetics
American Society for Microbiology

Grants

12/1993 - 03/2010	NIH-NIDCD R01DC02148, Molecular Analysis of Pathogens in Otitis Media by PCR, (Co-Investigator)

07/2000 - 11/2009	NIH-NIDCD- R01DC04173, The Role of Biofilms in the Pathogenesis of Otorrhea, (Co-Investigator)

07/2009 - 06/2011	NIH/NIAID R01 A1080935-01A1, Impact of Antibiotics and Vaccines on the in vivo Evolution of S. penumoniae, (Co-Investigator)

Perspectives and Editorials

Ehrlich, G.D., Hu, F.Z., Lin, Q., Costerton, J.W., and Post, J.C. Intelligent implants to battle biofilms. ASM News 70:127-133, 2004.

Publications

1. Hall BG, Ehrlich GD, Hu FZ. Pan-genome analysis provides much higher strain typing resolution than does MLST. Microbiology Dec 17 [Epub ahead of print], 2009.

2. Romero P, Croucher NJ, Hiller NL, Hu FZ, Ehrlich GD, Bentley SD, Garcia E, Mitchell TJ. Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages. J Bacteriol 191(15):4854-4862, 2009.

3. Arce FT, Carlson R, Monds J, Veeh R, Hu FZ, Stewart PS, Lal R, Ehrlich GD, Avci R. Nanoscale structural and mechanical properties of nontypeable Haemophilus influenzae biofilms. J Bacteriol 191(8):2512-2520, 2009.

4. Dice B, Stoodley P, Buchinsky F, Metha N, Ehrlich GD, Hu FZ. Biofilm formation by ica-positive and ica-negative strains of Staphylococcus epidermidis in vitro. Biofouling 25(4):367-375, 2009.

5. Shen K, Krakora SM, Cunningham M, Singh M, Wang X, Hu FZ, Post JC, Ehrlich GD. Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model. Orthod Craniofac Res 12:254-262, 2009.

6. Kerschner JE, Horsey E, Ahmed A, Erbe C, Khampang P, Cioffi J, Hu FZ, Post JC, Ehrlich GD. Gene expression differences in infected and non-infected middle ear complementary DNA libraries. Arch Otolaryngol Head Neck Surg, 135;1:33-39, 2009.

7. Satish L, Abdulally A, Oswald D, Johnson S, Hu FZ, Post JC, Ehrlich GD, Kathju S. Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing. Cell Stress Chaperones, 13(4):527-533, 2008.

8. Hall-Stoodley L, Nistico L, Sambanthamoorthy K, Dice B, Nguyen D, Mershon WJ, Johnson C, Hu FZ, Stoodley P, Ehrlich GD, Post JC. Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates. BMC Microbiol 8:173, 2008.

9. Ehrlich GD, Hiller NL, Hu FZ. What makes pathogens pathogenic. Genome Biol 9;6:225, 2008.

10. Satish L, LaFramboise WA, O’Gorman DB, Johnson S, Janto B, Gan BS, Baratz ME, Hu FZ, Post JC, Ehrlich GD, Kathju S. Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren’s contracture. BMC Med Genomics 1:10, 2008.

11. Forbes ML, Horsey E, Hiller NL, Buchinsky FJ, Hayes JD, Compliment JM, Hillman T, Ezzo S, Shen K, Keefe R, Barbadora K, Post JC, Hu FZ, Ehrlich GD. Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media. PLoS One 3;4:e1969, 2008.

12. Hu FZ, Ehrlich GD. Population-level virulence factors amongst pathogenic bacteria: Relation to infectious outcome. Future Microbiol 3(1):31-42, 2008.

13. Hogg JS, Hu FZ, Janto B, Boissy R, Hayes J, Keefe R, Post JC, Ehrlich GD. Characterization and modeling of the Haemophilus influenzae core and supra-genome supragenome based on the complete genomic sequences of Rd and 12 clinical nontypeable strains. Genome Biology 8(6):R103, 2007.

14. Buchinsky FJ, Forbes M, Hayes J, Hu FZ, Greenberg P, Post JC, Ehrlich GD. Phenotypic plurality among clinical strains of nontypeable Haemophilus influenzae determined by symptom severity in the chinchilla model of otitis media. BMC Microbiol 7:56, 2007.

15. Mußmann M, Hu FZ, Richter M, de Beer D, Preisler A, Jørgensen BB, Glöckner FO, Amann R, Koopman WJH, Janto B, Hogg JS, Boissy R, Lasken RS, Stoodley P, Ehrlich GD. Insights into the genome of large sulphur bacteria revealed by analysis of single filaments. PLoS Biology 5(9):e230, 2007.

16. Hiller NL, Janto B, Hogg JS, Boissy R, Yu S, Powell E, Keefe R, Ehrlich NE, Shen K, Hayes J, Barbadora K, Klimke W, Dernovoy D, Tatusova T, Parkhill J, Bentley SD, Post JC, Ehrlich GD, Hu FZ. Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: Insights into the pneumococcal supragenome 2. J Bacteriol 189;22:8186-8195, 2007.

17. Singh MK, Scott TF, LaFramboise WA, Hu FZ, Post JC, Ehrlich GD. Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing $-interferon therapy. J Neurol Sci 258L52-59, 2007.

18. Erdos G, Sayeed S, Hu FZ, Antalis PT, Shen K, Hayes JD, Ahmed AI, Johnson SL, Post JC, Ehrlich GD. Construction and characterization of a highly redundant Pseudomonas aeruginosa genomic library prepared from 12 clinical isolates: Application to studies of gene distribution among populations. Int J Pediatr Otorhinolaryngol 70:1891-1900, 2006.

19. Shen K, Sayeed S, Antalis P, Gladitz J, Ahmed A, Dice B, Janto B, Dopico R, Keefe R, Hayes J, Johnson S, Yu S, Ehrlich N, Jocz J, Kropp L, Wong R, Wadowsky RM, Slifkin M, Preston RA, Erdos G, Post JC, Ehrlich GD, Hu FZ. Infect Immun 74(9):5272-5283, 2006.

20. Donfack J, Buchinsky FJ, Derkay CS, Steinberg BM, Choi SS, Conley SF, Meyer CM, 3^rd, McClay JE, Campisi P, Hu FZ, Preston RA, Abramson AL, Ehrlich GD, Post JC. Four mutations in epidermodysplasia verruciformis 1 (EVER1) gene are not contributors to susceptibility in RRP. Int J Pediatr Otorhinolaryngol 70:1235-1240, 2006.

21. Kathju S, Satish L, Rabik C, Rupert T, Oswald D, Johnson S, Hu FZ, Post JC, Ehrlich GD. Identification of differentially expressed genes in scarless wound healing utilizing PCR suppression subtractive hybridization. Wound Rep Reg 14:413-420, 2006.

22. Allegrucci M, Hu FZ, Shen K, Hayes J, Ehrlich GD, Post JC, Sauer K. Phenotypic characterization of Streptococcus pneumonia biofilm development. J Bacteriol 188;7:2325-2335, 2006.

23. Shen K, Gladitz J, Antalis P, Dice B, Janto B, Keefe R, Hayes J, Ahmed A, Dopico R, Ehrlich N, Jocz J, Kropp L, Yu S, Nistico L, Greenberg DP, Barbadora K, Preston RA, Post JC, Ehrlich GD, Hu FZ. Characterization, distribution and expression of novel genes among eight clinical isolates of Streptococcus pneumoniae. Infect Immun 74;1:321-330, 2006.

24. Braxton E, Ehrlich G, Stoodley P, Hall-Stoodley L, Veeh R, Hu F, Fux C, Quigley M, Post JC. The role of biofilms in neurosurgical device-related infections. Neurosurg Rev 28;4:249-255, 2005.

25. Hu FZ, Nystrom A, Ahmed A, Palmquist M, Dopico R, Mossberg I, Gladitz J, Rayner M, Post JC, Ehrlich GD, Preston RA. Mapping of an autosomal dominant gene for Dupuytren’s contracture to chromosome 16q in a Swedish family. Clin Genet 68:424-429, 2005.

26. Ehrlich GD, Stoodley P, Kathju S, Zhao Y, Mcleod BR, Baliban N, Hu FZ, Sotereanos N, Costerton JW, Stewart PS, Post JC, Lin Q. Engineering approaches for the detection and control of orthopaedic biofilm infections. Clin Orthop 437:59-66, 2005.

27. Ehrlich GD, Hu FZ, Shen K, Stoodley P, Post JC. Bacterial plurality as a general mechanism driving persistence in chronic infections. Clin Orthop 437;20-24, 2005.

28. Stoodley P, Kathju S, Hu FZ, Erdos G, Levenson JE, Mehta N, Dice B, Johnson S, Hall-Stoodley L, Nistico L, Sotereanos N, Sewecke J, Post JC, Ehrlich GD. Molecular and imaging techniques for bacterial biofilms in joint arthroplasty infections. Clin Orthop 437:31-40, 2005.

29. Shen K, Antalis P, Gladitz J, Sayeed S, Ahmed A, Yu S, Hayes J, Johnson S, Dice B, Dopico R, Keefe R, Janto B, Chong W, Goodwin J, Wadowsky RM, Erdos G, Post JC, Ehrlich GD, Hu FZ. Identification, distribution, and expression of novel (nonRd) genes in ten clinical isolates of nontypeable Haemophilus influenzae. Infect Immun 73;6:3479-3491, 2005.

30. Gladitz J, Shen K, Antalis P, Hu FZ, Post JC, Ehrlich GD. Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzae. Nucleic Acids Res 33;11:3644-3658, 2005.

31. Hu FZ, Donfack J, Ahmed A, Dopico RJ, Johnson S, Post JC, Ehrlich GD, Preston RA. Fine mapping a gene for pediatric gastroesophageal reflux on human chromosome 13q14. Hum Genet 114;6:562-572, 2004.

32. Jiang S, Gitlin J, Deng FM, Liang FX, Lee A, Atala A, Bauer SB, Ehrlich GD, Feather SA, Goldberg JD, Goodship JA, Goodship TH, Hermanns M, Hu FZ, Jones KE, Malcolm S, Mendelsohn C, Preston RA, Retik AB, Schneck FX, Wright V, Ye XY, Woolf AS, Wu XR, Ostrer H, Shapiro E, Yu J, Sun TT. Lack of major involvement of human uroplakin genes in vesicoureteral reflux: Implications for disease heterogeneity. Kidney Int 66;1:10-19, 2004.

33. Erdos G, Sayeed S, Antalis P, Hu FZ, Hayes J, Goodwin J, Dopico R, Post JC, Ehrlich GD. Development and characterization of a pooled Haemophilus influenzae genomic library for the evaluation of gene expression changes associated with mucosal biofilm formation in otitis media. Int J Ped Oto 67;7:749-755, 2003.

34. Ehrlich GD, Veeh R, Wang X, Costerton JW, Hayes JD, Hu FZ, Daigle BJ, Ehrlich GD, Post JC. Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. JAMA 287:1710-1715, 2002.

35. Heike C, Seto M, Ehrlich GD, Preston RA, Hu FZ, Hing A, Jackson C, Palidin A, Cunningham M. Century of Jackson-Weiss syndrome: Further definition of clinical and radiographic findings in “lost” descendants of the original kindred. Am J Med Genetics 100:315-324, 2001.

36. Dry GM, Yasinskaya YI, Williams JK, Ehrlich GD, Preston RA, Hu FZ, Gruss JS, Ellenbogen R, Cunningham ML. Inhibition of apoptosis: A potential mechanism for syndromic craniosynostosis. Plast Reconstr Surg 107:425-32, 2001.

37. Ehrlich GD, Hu FZ, Preston RA, Post JC. The spectrum of pediatric gastroesophageal reflux. (letter) JAMA. Dec 27;284(24):3125, 2000.

38. Hu FZ, Post JC, Johnson S, Ehrlich GD, Preston RA. Reduction of the GER gene region on 13q 14 and exclusion of the 5-HT2A receptor gene as cause of hereditary severe pediatric gastroesophageal reflux. Hum Genet. 107:519-525, 2000.

39. Hu FZ, Preston RA, Post JC, White JG, Kikuchi L, Wang X, Self TW, Allen G, Stiffler RS, McGraw C, Pulsifer-Anderson EA, Ehrlich GD. Mapping of a gene for pediatric gastroesophageal reflux to chromosome 13q: A collaboration with a family self-help group. JAMA 284:325-334, 2000.

40. Darden DL, Hu F Z, Gorry MC, Dressman D, Li HS, Whitcomb DC, Dohar J, Ehrlich GD. RNA differential display of scarless wound healing in fetal rabbit indicates downregulation of a CCT chaperonin subunit and upregulation of a glycophorin-like gene transcript. J Pediatr Surg 35:406-419, 2000.

41. Ehrlich GD, Hoffman HJ, Zielke HR, White GJ, Hu FZ, Vigorito R, Dingman JR, Libert T, Smialek JE, Post JC. Molecular epidemiological studies of common bacterial and viral respiratory pathogens in sudden infant death syndrome (SIDS). Proceedings of the 7th International Symposium on Recent Advances in Otitis Media.

42. Hu FZ, Liu J. Management of intractable ulcer in diabetic patients with topical antibiotics, West China Medical Journal 2:113, 1996.

43. Hu FZ, Liu J, Fan X. Bacterial milieu in intractable wounds. West China Medical Journal 4:313, 1995.

44. Wang X, Wu Y, Fan X, Hu FZ, et al. Reducing the titer of intestinal bifidobacteria caused by digestive diseases. Chin J Microecology, 7(3):59, 1995.

Book Chapters

Ehrlich GD, Hu FZ, Post JC. Role for Biofilms in Infectious Disease. In Microbial Biofilms, ASM Press, pp. 332-358, 2004.

Presentations

1. Hu, F.Z., Darden, D.L., Gorry, M.C., Dressman, D., Li, H., Whitcomb, D.C., Dohar, J., Ehrlich, G.D. Identification of Genes Differentially Expressed in a Scarless Model of Wound Healing. Allegheny University of the Health Sciences Second Annual Research Conference, October 8-9, 1997, King of Prussia, Pennsylvania. (Poster)

2. Hu, F.Z., Darden, D.L., Gorry, M.C., Dressman, D., Li, H., Whitcomb, D.C., Dohar, J., Ehrlich, G.D. Identification of Genes Differentially Expressed in a Scarless Model of Wound Healing. ARO Mid-winter Meeting, St. Petersburg Beach, Florida, February 15-19, 1998. (Poster)

3. Hu, F.Z., Preston, R.A., White, G.J., Kikuchi, L., Allen, G., Neiswanger, K., Stiffler, R., Self, T., PAGER, Ehrlich, G.D., Post, J.C. Gene Mapping of Severe Pediatric Gastroesophageal Reflux. Annual Mid-winter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida, February 14, 1998.

4. Hu, F.Z., Preston, R.A., White, G.J., Kikuchi, L., Allen, G., Neiswanger, K., Stiffler, R., Self, T., PAGER, Ehrlich, G.D., Post, J.C. Gene Mapping of Severe Pediatric Gastroesophageal Reflux. Annual Mid-winter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida, February 14, 1999.

5. Ehrlich, G.D., Hoffman, H., Zilkie, R., White, G., Hu, F.Z., Vigarido, R., Post, J.C. Molecular Epidemiological Studies Of Common Bacterial and Viral Respiratory Pathogens In SIDS. 7th International Symposium on Recent Advances in Otitis Media. Ft. Lauderdale, Florida, June 1999.

6. Schneck, F.X., Preston, R. A., Hu, F.Z., Herz, D., Barmada, M., Aston, C., Post, J.C., Ehrlich, G.D. Putative Mapping of a Gene for Vesicoureteral Reflux to Chromosome 11. American Academy of Pediatrics Annual Meeting - Urology Section. Chicago, Illinois, October 31, 2000.

7. Ehrlich, G.D., Hayes, J., Veeh, R., Hu, F.Z., Wang, X., Costerton, J.W. Direct Electronmicrographic Imaging of Biofilms on the Middle-ear Mucosa. Annual Mid-winter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida, February 6, 2001.

8. Kathju, S., Rabik, C., Wang, X., Hayes, J., White, G.J., Johnson, S., Hu, F.Z., Post, J.C., Ehrlich, G.D. Molecular Analysis of Scarless Fetal Wound Healing. Annual Mid-winter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida, February 6, 2001.

9. Hu, F.Z., Preston, R.A., Johnson, S., Ahmed, A., Gladitz, J., Post, J.C., Ehrlich, G.D. Post-Genomic Strategy for the Positional Cloning of the Gene for Severe Pediatric GERD. American College of Gastroenterology, Las Vegas, Nevada, October 20-24, 2001.

10. Hu, F.Z., Nyström, A., Ahmed, A., Dopico, R., Mossberg, I., Palmquist, M., Gladitz, J., Rayner, M., Post, J.C., Preston, R.A., Ehrlich, G.D. Mapping a Gene for Dupuytren Contracture in Two Swedish Families. American Society for Human Genetics Annual Meeting, Baltimore, Maryland, October 15-19, 2002.

11. Erdos, G., Sayeed, S., Shen, K., Antalis, P., Hayes, J., Goodwin, J., Hu, F., Post, J.C., Ehrlich, G.D. Genomic Plasticity and Shifting Gene Expression Patterns in Biofilm Forming Pseudomonas aeruginosa, a Pathogen of Otorrhea. ARO Midwinter Meeting, Daytona Beach Florida, February 22-27, 2003.

12. Ehrlich, G.D., Weedn, V., Kathju, S., Peterson, J., Balaban, N., Shirtliff, M., Post, C., Lin, Q., Leduc, P., Hu, F.Z., Kaiser, T., Becker, J., Sotereanos, N., Costerton, W. Development of Intelligent Implants for Biofilm Prevention in Orthopedic Prostheses. ASM Conference on Bio-, Micro-, and Nanosystems, New York, New York, July 7-10, 2003.

13. Donfack J., Hu F.Z., Amed A., Dopico R., Post J.C., Ehrlich G.D., Preston R.A. Fine Mapping a Gene For Severe Pediatric Gastroesophageal Reflux On Human Chromosome 13q14. 53rd Annual Meeting of the American Society of Human Genetics, Los Angeles, California, November 4 - 8, 2003. (Poster)

14. Antalis, P., Gladitz, J., Shen, K., Hu, F.Z., Sayeed, S., Hayes, J., Ahmed, A., Johnson, S., Dopico, R., Chong, W., Goodwim , J., Singh, M., Post, J.C., Ehrlich, G.D., Erdos, G. Demonstration of Extensive Genomic Plasticity Among Clinical Isolates of Haemophilus influenzae and Evidence for a Population-Based Supra-Genome. ASM Biofilms 2003 Victoria Island, British Columbia, Canada, Oct 31-Nov 2, 2003.

15. Hu, F.Z. Introduction of Human Genetic Science, CGS Faculty Retreat, Pittsburgh, Pennsylvania, March 2, 2004.

16. Singh, M. K., LaFramboise, W.A., Hu, F.Z., Scott, T.F., Post, J.C., Ehrlich, G.D. Gene Expression Changes in Peripheral Blood Mononuclear Cells from Multiple Sclerosis Patients Undergoing ß-interferon. 56^th Annual Meeting of the American Academy of Neurology, April 2004.

17. Bennett, J., Hiller, N.L., Eutsey, R., Powell, E., Hu, F.Z., Ehrlich, G.D. Identification of a Candidate Host-Interacting Protein Family in Haemophilus influenzae. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 15, 2008. (Poster)

18. Boissy, R., Hiller, N.L., Hogg, J., Ahmed, A., Powell, E., Janto, B., Hayes, J., Yu, S., Post, J.C., Hu, F.Z., Ehrlich, G.D. Comparative Genomic Analyses of Seventeen Staphylococcus aureus Strains Using the Finite Supragenome Model. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 15, 2008. (Poster)

19. Buchinsky, F.J., Donfack, J., Derkay, C.S., Choi, S.S., Conley, S.F., Myer, C.M. III, McClay, J.E., Campisi, P., Wiatrak, B.J., Sobol, S.E., Schweinfurth, J.M., Tsuji, D.H., Hu, F.Z., Rockette, H.E., Ehrlich, G.D., Post, J.C. Age of Child, More than HPV Type, is Associated with Clinical Course in Recurrent Respiratory Papillomatosis. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 15, 2008. (Poster)

20. Ahmed, A., Earl, J., Powell, E., Boissy, R., Rabe, L., Janto, B., Hillier, S., Ehrlich, GD., Hu, F.Z. Comparative Genomic Analyses of 10 Clinical Isolates of Gardnerella vaginalis Demonstrate Extremely High Levels of Variability within the Species Leading to a Very Small Core Genome and a Very Large Supragenome. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 7, 2009. (Poster)

21. Powell, E., Eutsey, R., Hiller, N.L., Bennett, J., Janto, B., Hillman, T., Ezzo, S., Tomasz, A., Hu, F.Z., Ehrlich, G.D. Role of the Capsule in the Virulence Difference Between Closely Related Streptococcus pneumonia Stains SV35 and SV36. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 7, 2009. (Poster)

22. Bennett, J., Hiller, N.L., Eutsey, R., Powell, E., Longwell, M., Janto, B., Boissy, R., Buchinsky, F., Hillman, T., Ehrlich, G.D., Hu F.Z. Identification of a Haemophilus influenzae Virulence Gene Family. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 7, 2009. (Poster)

23. Hiller, N.L., Ahmed, A., Powell, E., Eutsey, R., Earl, J., Janto, B., Boissy, R., Hogg, J., Barbadora, K., Post, J.C., Hu, F.Z., Ehrlich, G.D. Evolution of Streptococcus pneumoniae Via Horizontal Gene Transfer During a Chronic Polyclonal Pediatric Infection. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 7, 2009. (Poster)

24. Eutsey, R., Hiller, N.L., Dahlgren, M., D’Aco, K., Hu, F.Z., Post, J.C., Ehrlich, G.D. Supragenome Arrays for Assessing the Genic Content of Haemophilus influenzae Strains. Discovery Day, Drexel University College of Medicine, Philadelphia, Pennsylvania, October 7, 2009. (Poster)

Invited Presentations

1. Hu, F.Z. TDT and Case-Control Association Studies to Fine Map the GERD 1 Gene on Chromosome 13q14, Shantou University, Shantou China, October 9, 2003.

2. Hu, F.Z. Genetics of Severe Pediatric Gastroesophageal Reflux. Department of Gastroenterology, Baylor College of Medicine, July 2, 2001.

3. Hu, F.Z. A Post-Genomics Approach to Positionally Cloning the Pediatric GERD Gene at Chromosome 13q14, AstraZeneca, Molndal, Sweden, October 31, 2000.

4. Hu, F.Z. Mapping a Gene for Severe Pediatric Gastroesophageal Reflux, West China University of the Medical Sciences, Chengdu, Sichuan, CHINA, October 12, 1999.

Computer Programs Designed

GetSizes - Visual BASIC program designed to make allele calls and zygosity determinations from ABI-generated genotyping data. This program is over 98% accurate and compares very favorably with commercial software products costing tens of thousands of dollars.

GetCalls - Visual BASIC program designed to sort the alleles for a given marker by size, perform a rounding function, and then check and verify inheritance within the family, such that an inspection is performed to ensure that the children's alleles correspond to the parents bin allelic data, and convert data to a format read for LINKAGE.

CheckInherit - Visual BASIC program designed to test families for allowable alleles based upon parentage - to be used before submitting genotypic data to LINKAGE.

MakeLink - Visual BASIC program to convert genotyping data into correct file format for submission to LINKAGE.

GetLods - Visual BASIC program designed to interface with LINKAGE and extract lod scores into a tabular form and highlight scores differentially depending on significance.

QbotRearray - Visual BASIC program to automatically take normalization data from hybridization films and use it to re-program the arraying robot to rearray cDNA libraries leaving out the highly expressed clones.

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