Latha Satish, Ph.D.

Education

Research Interest

• Biology of scarless wound healing

Current Project

• Identifying novel genes that are responsible for scarless wound healing

Honors & Awards

• 3M Fellowship Award funded ($15,000) by the 3M Health Care for the year 2007
• Best paper award for the paper presented at the 51^st Annual Meeting of the Plastic Surgery Research Council, Danapoint, CA, 2006
• Third Place for the Paper presented at the 14th Annual Pathology Research Day Symposium, University of Pittsburgh, 2003
• Awarded Pathology Post Doctoral Travel Grant, University of Pittsburgh, 2003
• Awarded Pathology Post Doctoral Research Training Grant, University of Pittsburgh, 2003
• First Place for the Paper presented at the 13th Annual Pathology Research Day symposium, University of Pittsburgh, 2002
• Best Paper Award -Vth National Academy of Burns Conference, Chennai, India, 1998
• Awarded Senior Research Fellowship from Council of Scientific and Industrial Research, Government of India, 1994

Professional Memberships

• Member of Wound Healing Society
• Member of American Society of Cell Biology
• Member of Indian Wound Healing Society

Publications

Satish L, Abdulally A, Oswald D, Johnson S, Hu FZ, Post JC, Ehrlich GD, Kathju S (2008).  Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing.  Cell Stress Chaperones, 13(4):527-533.

Satish L, LaFramboise WA, O’Gorman DB, Johnson S, Janto B, Gan BS, Baratz ME, Hu FZ, Post JC, Ehrlich GD, Kathju S. (2008).  Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren’s contracture.  BMC Med Genomics 1:10.

Satish L, Lyons-Weiler J, Hebda PA, Wells A (2006). Gene expression patterns in isolated keloid fibroblasts.  Wound Rep Reg, 14: 463-470.

Kathju S, Satish L, Rabik C, Rupert T, Oswald D, Johnson S, Hu FZ, Post JC, Ehrlich GD (2006).  Identification of differentially expressed genes in scarless wound healing utilizing polymerase chain  reaction-suppression subtractive hybridization.  Wound Rep Reg, 14: 413-420.

Satish L, Blair HC, Glading A, Wells A (2005).  IP-9 (CXCL11) induced cell motility in keratinocytes requires calcium flux-dependent activation of µ-calpain.  Mol Cell Biol, 25: 1922-1941.

Satish L, Kharait S, Bodnar R (2004). Cell motility as a regulatable target during wound healing. Recent Research Developments in Cell Biology. 2: 37-70 ISBN: 81-7895-142-148.

Wells A, Kharait S, Yates C, Satish L (2004). Calpain proteases in prostate carcinomas. In: Immunohistochemistry and In Situ Hybridization of Human Carcinomas, Volume 1 (Ed: MA Hayar, Elsevier Science/Academic Press).

Satish L, Babu M, Tran K, Hebda P, Wells A (2004).  Keloid fibroblasts responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways.  Wound Rep Reg, 12: 183-192.

Glading A, Bodnar RJ, Reynolds IJ, Shiraha H, Satish L , Potter DA, Blair HC, Wells A (2004). Epidermal growth factor activates m-calpain (calpain II) atleast in part, by extracellular signal-regulated kinase-mediated phosphorylation.  Mol Cell Biol, 24: 2449-2512.

Tran KT, Rusu SD, Satish L, Wells A (2003).  Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity.  Exp Cell Res, 289: 359-367.

Satish L, Yager D, Wells A (2003).  ELR-negative CXC chemokine IP-9 as a mediator of epidermal-dermal communication during wound repair.  J Invest Dermatol, 120: 1110-1117.

Latha B,  Babu M (2001).  The involvement of free radicals in burn injury:  A review.  Burns, 27: 309-317.

Latha B, Ramakrishnan M, Jayaraman V, Babu M (1999).  Physicochemical properties of extracellular matrix proteins in postburn human granulation tissue.  Comp Biochem Physiol. 124: 241-249.

Latha B, Ramakrishnan M, Jayaraman V , Babu M (1998).  Efficacy of trypsin:chymotrypsin preparation in the reduction of oxidative damage during burn injury in humans.  Burns, 24: 532-538.

Latha B, Ramakrishnan M, Jayaraman V, Babu M (1997).  Serum enzymatic changes modulated using trypsin:chymotrypsin preparation during burn wounds in humans.  Burns, 7/8: 560-564.

Latha B, Ramakrishnan M, Jayaraman V, Babu M (1997).  Action of trypsin:chymotrypsin (Chymoral forte D.S.) preparation on acute phase proteins following burn injury in humans.  Burns, 23: S3-S7.

Invited Speaker

• Wound Healing Society Educational Symposium (Tampa, FL, 2007)
• M.I.R.M. Wound Healing Research Conference (Pittsburgh, PA, 2006)
• Wound Healing Society Educational Symposium (Scottsdale, AZ, 2006)
• M.I.R.M. Wound Healing Research Conference (Pittsburgh, PA, 2004)
• WoundCon (Chennai, India, 2003)
• Wound Healing Society Educational Symposium (Seattle, WA, 2003)
• M.I.R.M. Wound Healing Research Conference (Pittsburgh, PA, 2002)
• Wound Healing Society Educational Symposium (Baltimore, MD, 2002)
• 12th Annual Pathology Research Conference (Pittsburgh, PA, 2001)
• Wound Healing Society Educational Symposium (Albuquerque, NM, 2001)
• VIth National Academy of Burns conference (Chennai, India, 1998)

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