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Natalia Luisa Hiller, Ph.D.
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B.S.
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Biology, Pomona College, Claremont,
California
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Ph.D.
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Immunology and Microbial Pathogenesis, Northwestern University Medical
School, Chicago, Illinois
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Research Interests
- Molecular Pathogenesis
- Bioinformatics
Current Project
- Study the interactions between
microorganisms and their hosts using comparative genomics.
Honor & Awards
- Predoctoral Fellowship, American Heart
Association, Chicago,
IL
- Predoctoral Fellowship (top 2.8%),
American Heart Association, Chicago,
IL
- Northwestern University
Scholar Award, Chicago,
IL
- Northwestern University
Scholar Award, Chicago,
IL
- Alfred P. Sloan Foundation,
Gordon Conference, Il Ciocceo, Italy
- Travel Award, Northwestern
University, Chicago,
IL
- Award for Best Student Poster,
Northwestern Pathology Retreat, Chicago,
IL
- Center for Genetic Medicine
Travel Award, Northwestern University, Chicago, IL
- ASTMH Award for Scientific
Excellence, Molecular Parasitology Mtg., Woods
Hole, MA
Professional Memberships
- American Society for
Microbiology
- American Association for the
Advancement of Science
Publications
Lauer S, VanWye J,
Harrison T, McManus H, Samuel BU, Hiller NL, Mohandas N, Haldar K. Vacuolar uptake of host components, and a role
for cholesterol and sphingomyelin in malarial
infection. EMBO J 19;14:3556-3564, 2000.
Haldar K, Samuel BU, Mohandas N, Harrison
T, Hiller NL. Erythrocytic vacuolar rafts
induced by malaria parasites. Curr Opin Hematol 8;2:92-97, 2001.
Haldar K, Samuel BU, Mohandas N, Harrison
T, Hiller NL. Transport mechanisms in plasmodium-infected erythrocytes:
Lipid rafts and a tubovesicular network. Int J Parasitol 31;12:1393-1401, 2001.
Haldar K, Mohandas N, Samuel BU, Harrison T, Hiller
NL, Akompong T, Cheresh
P. Protein and lipid trafficking induced in erythrocytes infected by malaria
parasites. Cell Microbiol 4;7:383-395,
2002.
Hiller NL, Akompong T, Morrow JS, Holder AA,
Haldar K. Identification of a stomatin
orthologue in vacuoles induced in human
erythrocytes by malaria parasites: A role for microbial raft-proteins in apicomplexan vacuole biogenesis. J Biol
Chem 278;48:48413-48421,
2003.
Hiller NL, Bhattacharjee S, van Ooij C, Liolios K, Harrison T,
Lopez-Estrano C, Haldar K. A host-targeting signal in virulence
proteins reveals a secretome in malarial infection.
Science 306;5703:1934-1937, 2004. This article was
highlighted in Nature Reviews Microbiology 3, 97-98, 2005.
Haldar K, Hiller NL, van Ooij
C, Bhattacharjee S. Plasmodium parasite proteins
and the infected erythrocyte. Trends Parasitol 21;9:402-403, 2005.
Murphy SC, Hiller NL, Harrison T, Lomasney
JW, Mohandas N, Haldar K. Lipid rafts and malaria
parasite infection of erythrocytes. Mol Membr Biol 23;1:81-88, 2006.
Bhattacharjee S*, Hiller NL*, Liolios K, Win J, Kanneganti
TD, Young C, Kamoun S, Haldar
K. The malarial host-targeting signal is conserved in the Irish potato famine
pathogen. PLOS Pathogens 2;5:e50, 2006. * Equally
contributing authors. This article was selected for Editor's Choice in
Science 312; 5780: 1574, 2006.
Haldar K, Kamoun S, Hiller
NL, Bhattacharje S, van Ooij
C. Common infection strategies of pathogenic eukaryotes. Nat Rev Microbiol 4;12:922-931, 2006.
Buchinsky FJ, Forbes ML, Hayes JD, Shen K, Ezzo S, Compliment J,
Hogg J, Hiller NL, Hu FZ, Post JC, Ehrlich
GD. Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus
influenzae assessed using the chinchilla laniger model of otitis media.
BMC Microbiol 7:56, 2007.
Hiller NL, Janto B, Hogg JS, Boissy R, Yu S, Powell E, Keefe R, Ehrlich NE, Shen K, Hayes J, Barbadora K, Klimke W, Dernovoy D, Tatusova T, Parkhill J, Bentley
SD, Post JC, Ehrlich GD, Hu FZ. Comparative genomic
analyses of seventeen Streptococcus pneumoniae
strains: Insights into the pneumococcal supragenome.
J Bacteriol 189(22):8186-8195, 2007.
Pollard AM,
Onatolu KN, Hiller L, Haldar
K, Knoll LJ. Highly polymorphic
family of glycosylphosphatidylinositol-anchored
surface antigens with evidence of developmental regulation in Toxoplasma gondii. Infect Immun
76;1:103-110, 2007.
Forbes ML, Horsey E, Hiller NL, Buchinsky FJ, Hayes JD, Compliment JM, Hillman T, Ezzo S, Shen K, Keefe R, Barbadora K, Post JC, Hu FZ,
Ehrlich GD. Strain-specific
virulence phenotypes of Streptococcus pneumoniae
assessed using the Chinchilla laniger model
of otitis media. PLoS One 3;4:e1969, 2008.
van Ooij C, Tamez P, Bhattacharjee S, Hiller NL, Harrison T, Liolios K, Kooij T, Ramesar J, Balu B, Adams J,
Waters A, Janse C, Haldar
K. The malaria secretome:
From algorithms to essential function in blood stage infection. PLoS Pathog 4(6):e1000084, 2008.
Ehrlich GD, Hiller NL, Hu FZ. What
makes pathogens pathogenic. Genome Biol
9;6:225, 2008.
Tamez PA, Bhattacharjee S, van Ooij C, Hiller NL, LlinVs M, Balu B, Adams JH, Haldar K. An
erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell
surface. PLoS
Pathog 4;8:e1000118, 2008.
Romero P, Croucher
NJ, Hiller NL, Hu FZ, Ehrlich GD, Bentley SD, Garcia E, Mitchell
TJ. Comparative genomic analysis
of ten Streptococcus pneumoniae
temperate bacteriophages. J Bacteriol
191(15):4854-4862, 2009.
Selected Presentations and Abstracts
N. Luisa Hiller, T. Akompong, C.
Olson, I.T. Ling, A.A. Holder, K. Haldar.
Cholesterol Rafts in Apical Organelles of Plasmodium falciparum.
American Society of Hematology, Philadelphia,
PA, 2002, Poster.
N. Luisa Hiller, T. Akompong, C. Olson, I.T.
Ling, A.A. Holder, K. Haldar. The Apical Organelles
of the Malaria Parasite Contain Cholesterol-Rich Detergent Resistant
Membranes Which May Play a Role in the Intraerythrocytic
Development. Gordon Red Cell Conference, Il Ciocco, Italy, 2003, Poster.
N. Luisa Hiller, Irene Ling, Jon S. Morrow, Anthony A. Holder and Kasturi Haldar. A Malarial
Homologue of Stomatin: Implications for Parasite
Vacuolar Development. Molecular Parasitology
Meeting, Woods Hole, MA, 2003.
N. Luisa Hiller, Travis Harrison, Sean Murphy, Benjamin Samuel, Thomas
Akompong, Heidi Hamm, Narla
Mohandas, Anthony Holder, Jon Morrow, Jon Lomasney,
and Kasturi Haldar.
Raft-based, erythrocyte G protein signaling in malarial infection. American
Society of Hematology, San Diego,
CA, 2003, Poster.
N. Luisa Hiller, Thomas Akompong, Jon S.
Morrow, Anthony A. Holder, and Kasturi Haldar. A Malarial Homologue of Stomatin:
Implications for Parasite Vacuolar Development. Molecular Approaches to
Malaria Meeting, Lorne, Australia, 2004. Presented talk
and poster.
N. Luisa Hiller, Christiaan van Ooij, Souvik Batthacharjee, Konstantinos Liolios, Travis Harrison, Carlos Lopez-Estrano and Kasturi Haldar. A secretome linked to
targeting parasite proteins to the erythrocyte in malarial infection.
Molecular Parasitology Meeting, Woods Hole, MA and
ASTMH Meeting, Miami Beach,
FL, 2004.
Sean C Murphy, N. Luisa Hiller, Paul Chung, S.N. Prasana
Murthy, Alex Brown, Heidi E Hamm, Jon W. Lomasney, Kasturi Haldar. Multiple
signaling intermediates regulate invasion of human erythrocytes by Plasmodium
falciparum. Molecular Parasitology
Meeting, Woods Hole, MA, 2005.
Souvik Bhattacharjee, N.
Luisa Hiller, Konstantinos Liolios,
Sophien Kamoun, Kasturi Haldar. Involvement of
the P. falciparum host-targeting signal in a
eukaryotic secretion system shared with plant pathogenic oomycetes.
Molecular Parasitology Meeting, Woods Hole, MA,
2005.
Christiaan van Ooij, N.
Luisa Hiller, Souvik Bhattacharjee,
Travis Harrison, Konstantinos Liolios,
Laura Knoll, Elizabeth Glass, Natalia Maltsev, Joe
Win, Thirumala-Devi Kanneganti,
Carolyn Young, Sophien Kamoun
and Kasturi Haldar.
Conservation of pathogenic secretion signals of eukaryotic microbes used to
access animal and plant hosts. Great Lakes Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research,
Hilton Head, SC, 2005.
N. Luisa Hiller, Justin Hogg, Benjamin Janto,
Jennifer Bennett, Rory Eutsey, Azad Ahmed, Garth
Ehrlich, Fen Z. Hu. Identification of a
host-interacting protein family in Haemophilus
influenzae. 107th General Meeting of the
American Society for Microbiology, Toronto,
Canada, 2007,
Poster.
Bennett
J, Hiller NL, Eutsey
R, Powell E, Hu FZ, Ehrlich GD. Identification of a candidate
host-interacting protein family in Haemophilus influenzae.
Discovery Day, Drexel University College
of Medicine, Philadelphia,
PA, October 15, 2008, Poster.
Boissy R, Hiller
NL, Hogg J, Ahmed A, Powell E, Janto B, Hayes
J, Yu S, Post JC, Hu FZ, Ehrlich GD. Comparative genomic analyses of
seventeen Staphylococcus aureus strains using the finite supragenome
model. Discovery Day, Drexel University
College of Medicine, Philadelphia, PA,
October 15, 2008, Poster.
Powell
E, Eutsey R, Hiller
NL, Bennett J, Janto B, Hillman T, Ezzo S, Tomasz A, Hu FZ,
Ehrlich GD. Role of the capsule
in the virulence difference between closely related Streptococcus pneumonia strains SV35 and SV36. Discovery Day, Drexel
University College
of Medicine, Philadelphia,
PA, October 7, 2009, Poster.
Bennett
J, Hiller NL, Eutsey
R, Powell E, Longwell M, Janto
B, Boissy R, Buchinsky F,
Hillman T, Ehrlich GD, Hu FZ. Identification of a Haemophilus influenzae
virulence gene family. Discovery
Day, Drexel University
College of Medicine, Philadelphia, PA,
October 7, 2009, Poster.
Hiller NL, Ahmed A, Powell E, Eutsey RA, Earl J, Janto B, Boissy R, Hogg J, Barbadora K,
Post JC, Hu FZ, Ehrlich GD. Evolution of Streptococcus pneumoniae via horizontal
gene transfer during a chronic polyclonal pediatric infection. Discovery Day, Drexel
University College
of Medicine, Philadephia,
PA, October 7, 2009, Poster.
Eutsey R, Hiller
NL, Dahlgren M, D’Aco K, Hu FZ, Post JC, Ehrllich
GD. Surpagenome
arrays for assessing the genic content of Haemophilus influenzae
strains. Discovery Day, Drexel University
College of Medicine, Philadelphia, PA,
October 7, 2009, Poster.
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